Rubber Stoppers Manufacturer in India – Pharmaceutical Vial, Lyophilization & Infusion Stoppers
Rubber stoppers, also called rubber vial stoppers or rubber closures, are the primary closure for injection vials, infusion bottles and diagnostic tubes. Pressed into the neck of the container and held in place by an aluminium or flip-off seal, the stopper keeps the drug sterile, stops moisture and oxygen getting in, and lets a needle pierce it cleanly and reseal after withdrawal.
ARPL molds rubber stoppers in halobutyl (bromobutyl and chlorobutyl), silicone and natural rubber compounds, in standard neck sizes and fully custom geometries. Every lot is molded, trimmed and washed under controlled conditions with full batch traceability.
Available Rubber Stopper Materials
About ARPL Rubber Stoppers & Vial Stoppers
ARPL manufactures rubber stoppers and vial stoppers for pharmaceutical, diagnostic and laboratory packaging. Our range covers serum (two-leg and three-leg) stoppers for injection vials, igloo and slotted lyophilization stoppers for freeze-dried products, infusion stoppers for IV bottles, and plain or flanged stoppers for blood collection and sample tubes.
Stopper geometry is held to tight tolerances on plug diameter, flange thickness and penetration area, so the closure seats evenly on the vial neck, survives crimping and gives consistent needle penetration force. Penetration targets and fragmentation (coring) performance are designed in at the tooling stage, and stoppers can be supplied with target-ring marks for the needle insertion point.
Compounds are selected for low extractables, low particulate generation and compatibility with the drug product. Stoppers can be supplied siliconized for machine feeding and are compatible with steam (autoclave), gamma and EtO sterilization depending on compound. Test reports and compound documentation are provided against the customer's specification and the relevant pharmacopoeia requirements.
With in-house tool design, compression and injection molding, trimming and washing, ARPL supports pharmaceutical packagers and device makers from sampling through validation batches to regular production.
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Frequently Asked Questions
Answers to common questions about pharmaceutical rubber stoppers, vial stoppers and lyophilization stoppers
Rubber stoppers are the primary closure for injection vials, infusion bottles and diagnostic tubes. They keep the contents sterile, block moisture and oxygen, allow a needle or spike to pierce the closure and reseal afterwards.
Halobutyl rubbers (bromobutyl and chlorobutyl) have very low gas and moisture permeability and low levels of extractables, which protects sensitive drugs over their shelf life. That is why they are the standard compounds for parenteral packaging.
We make 13mm and 20mm serum and lyophilization stoppers for injection vials, 28mm and 32mm infusion stoppers, and custom sizes for tubes, bottles and laboratory glassware. New sizes can be tooled to your drawing.
A lyophilization (freeze-drying) stopper has vents or slots in its plug so it can sit half-inserted in the vial during freeze-drying, letting water vapour escape. At the end of the cycle the shelves press the stopper fully into the vial to seal it.
Yes. Depending on the compound, ARPL stoppers are compatible with steam (autoclave), gamma irradiation and ethylene oxide sterilization. Silicone stoppers can withstand repeated autoclave cycles.
Yes. In pharmaceutical packaging the terms rubber stopper, rubber closure and vial closure are used for the same part: the elastomeric plug that seals a vial, bottle or tube and is held in place by an aluminium or flip-off seal.
RFS (Ready for Sterilization) stoppers are washed and siliconized so the filler only has to sterilize them before use. RFU (Ready to Use) stoppers are also sterilized and packed in sealed bags so they can go straight onto the filling line. Let us know which processing level your line needs when you request a quote.
Yes. Our engineering team designs tooling for custom plug diameters, flange profiles, vent styles and penetration zones, and can supply samples for your container closure integrity and compatibility testing.